Recurrence of primary glomerulonephritis: Review of the current evidence

Figure 5 Histological changes of membranoproliferative glomerulonephritis in kidney transplant biopsies. Typical LM, EM and IF finding in cases previously classified as MPGN. First panel shows a case reclassified as ICGN with C3 abnormalities, including (A) the classic MPGN pattern GN on LM (B) large sub-endothelial electron dense deposits on EM and granular mesangial and capillary wall staining for both (C) IgG and (D) C3 on IF. Second panel shows a case reclassified as a C3 glomerulopathy, with (E) a similar MPGN pattern on LM, (F) smaller sub-endothelial deposits on EM and granular mesangial and capillary wall staining for (G) C3, but no significant staining for (H) IgG. Adapted from Alasfar et al[30] with permission. LM: Light microscopic; EM: Electron microscopy; IF: Immunofluorescence.