Dengue in renal transplant recipients: Clinical course and impact on renal function

Table 1 Characteristics of kidney transplant patients with dengue diagnosis in the period from January 2007 to July 2012 n (%)

Characteristics	n = 11
Age in years-mean (variation)	41.3 (19-61)
Female gender	7 (63.3)
Transplant time in years - mean (variation)	3.6 (1 mo-9 yr)
Deceased donor	9 (82.0)
Thymoglobulin induction	4 (36.6)
Immunosuppressive regimens
PRED + TAC + MMF	4 (36.3)
PRED + CYA + AZA	2 (18.1)
PRED + TAC + MPS	2 (18.1)
TAC + MMF	1 (9.0)
PRED + AZA + SRL	1 (9.0)
CYA	1 (9.0)
Rejection before dengue	3 (27.2)
Clinical findings
Fever	11 (100.0)
Myalgia	10 (91.0)
Headache	6 (54.5)
Abdominal pain	3 (27.2)
Bleedings	3 (27.2)
Nauseas and vomiting	2 (18.1)
Postural hypotension	2 (18.1)
Pleural effusions	2 (18.1)
Laboratory outcomes
Thrombocytopenia	9 (81.8)
Severe Thrombocytopenia (< 50000/mm3)	4 (36.6)
Leucopenia	4 (36.6)
Hemoconcentration	4 (36.6)
Transaminases increase (AST;ALT)	7 (63.6)
AST value, mean (variation) UI/L	130 (17-360)
ALT value, mean (variation) UI/L	100 (14-230)
Hospitalization	9 (81.8)
Hospitalization time in d, mean(variation)	14.2 (3-45)
Classification of dengue cases
Classical dengue	9 (81.8)
DHF	2 (18.1)
Dengue with complication	0

PRED: Prednisone; TAC: Tacrolimus; MMF: Mycophenolate mofetil; CYA: Cyclosporine; AZA: Azathioprine; MPS: Mycophenolate sodium; SRL: Sirolimus; AST: Aminotransferase alanine; ALT: Aminotransferase aspartate; DHF: Dengue hemorrhagic fever.