Retrospective Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Feb 24, 2017; 7(1): 57-63
Published online Feb 24, 2017. doi: 10.5500/wjt.v7.i1.57
Dengue in renal transplant recipients: Clinical course and impact on renal function
Paula Frassinetti Castelo Branco Camurça Fernandes, Reed André Siqueira, Evelyne Santana Girão, Rainne André Siqueira, Márcia Uchoa Mota, Leyla Castelo Branco Fernandes Marques, Silvana Cristina Albuquerque Andrade, Wilson Mendes Barroso, Sônia Leite Silva, Bruno Gomes Rodrigues dos Santos, Claúdia Maria Costa de Oliveira
Paula Frassinetti Castelo Branco Camurça Fernandes, Evelyne Santana Girão, Márcia Uchoa Mota, Leyla Castelo Branco Fernandes Marques, Silvana Cristina Albuquerque Andrade, Wilson Mendes Barroso, Sônia Leite Silva, Bruno Gomes Rodrigues dos Santos, Claúdia Maria Costa de Oliveira, Kidney Transplant Unit, Hospital Universitário Walter Cantídio, Universidade Federal do Ceará, Fortaleza, CE 60430-370, Brazil
Paula Frassinetti Castelo Branco Camurça Fernandes, Wilson Mendes Barroso, Department of Nephrology of Universidade Estadual do Ceará, Fortaleza, CE 60430-370, Brazil
Reed André Siqueira, Rainne André Siqueira, Universidade Estadual do Ceará, Fortaleza, CE 60430-370, Brazil
Author contributions: Fernandes PFCBC, Girão ES and de Oliveira CMC study conception and design; Siqueira RA, Siqueira RA, Mota MU, Marques LCBF, Andrade SCA, Barroso WM and Silva SL contributed to acquisition of data; Fernandes PFCBC, Girão ES, Siqueira RA, Siqueira RA and de Oliveira CMC contributed to analysis and interpretation of data; Siqueira RA, Siqueira RA, Girão ES, Fernandes PFCBC, Rodrigues dos Santos BG and de Oliveira CMC contributed to drafting of manuscript; Fernandes PFCBC, Girão ES, Rodrigues dos Santos BG and de Oliveira CMC contributed to critical revision.
Institutional review board statement: The study was reviewed and approved by Hospital Universitário Walter Cantídio/Universidade Federal do Ceará.
Informed consent statement: As the data collected was anonymous and retrospective, the Institutional Board waived it from this research.
Conflict-of-interest statement: The authors report no any conflicts of interest. This study is the result of our daily work in the HUWC renal transplant ward and received no funding whatsoever.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Bruno Gomes Rodrigues dos Santos, MD, Kidney Transplant Unit, Universitário Walter Cantídio, Hospital Universidade Federal do Ceará, Rua Capitão Francisco Pedro, 1290 - Rodolfo Teófilo, Fortaleza, CE 60430-370, Brazil. bgomesantos@hotmail.com
Telephone: +55-85-999466469
Received: July 29, 2016
Peer-review started: July 31, 2016
First decision: September 2, 2016
Revised: October 21, 2016
Accepted: January 11, 2017
Article in press: January 13, 2017
Published online: February 24, 2017
Processing time: 207 Days and 10.3 Hours
Abstract
AIM

To present clinical characteristics from renal transplant recipients with dengue fever and its impact on graft function.

METHODS

We retrospectively evaluated 11 renal transplant recipients (RTR) with dengue infection confirmed by laboratory test, between January 2007 and July 2012, transplanted in the Renal Transplant Center of Walter Cantídio University Hospital from Federal University of Ceará.

RESULTS

Positive dengue serology (IgM) was found in all patients. The mean time between transplant and dengue infection was 43 mo. Fever was presented in all patients. Nine patients presented with classical dengue and two (18%) with dengue hemorrhagic fever. All cases had satisfactory evolution with complete recovery of the symptoms. The time for symptom resolution varied from 2 to 20 d, with an average of 9 d. An increase of creatinine after the infection was observed in three (27.2%) patients with no clinically impact on the kidney graft function.

CONCLUSION

RTR with dengue infection seems to have a clinical presentation and evolution similar to those seen in the general population, with no long-term damage to patient and to the graft.

Keywords: Kidney; Renal; Transplant; Dengue; Clinical; Brazil

Core tip: Dengue is a viral arthropod-borne disease transmitted by mosquitoes of the genus Aedes, mainly Aedes aegypti. The kidney is the most transplanted solid organ in the world with approximately 79000 transplants performed annually. Data are lacking on the clinical presentation of dengue in renal transplant recipients. We retrospectively evaluated 11 renal transplant recipients with dengue infection confirmed by laboratory test, between January 2007 to July 2012, transplanted in the Renal Transplant Center of a tertiary hospital in northeast Brazil.