Towards curing type 1 diabetes: Prospects and challenges of allogeneic or xenogeneic donor islet cell transplantation

Figure 4 Preclinical proof-of-concept of human pluripotent stem cell-derived insulin secreting cells for blood glucose normalisation. Using transplantation of human foetal pancreas tissues in mice as a positive control[95], human pluripotent stem cell-derived pancreatic endoderm precursors required 110-140 days for blood glucose normalisation in diabetic mice[96], whereas human pluripotent stem cell-derived insulin secreting cells (known as SC-β cells or islets) required approximately 92-123 days for blood glucose normalisation[97]. hPSC: Human pluripotent stem cell; PEP: Pancreatic endoderm precursor.