Primary graft dysfunction following lung transplantation: From pathogenesis to future frontiers

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World Journal of Transplantation

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2220-3230

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Transplant. Mar 18, 2023; 13(3): 58-85
Published online Mar 18, 2023. doi: 10.5500/wjt.v13.i3.58

Table 5 Differences between the ex-vivo lung perfusion protocols

Description	Lund	OCS	Toronto
Year	2001[176]	2011[222]	2008[177]
Perfusion parameters
Perfusate	CellularSteen solution + RBCs	CellularOCS proprietary solution + RBCs	AcellularSteen solution
Target haematocrit	14%	15%-25%	N/A
Target flow	100% cardiac output	2.0-2.5 L/min	40% cardiac output
PA pressure	≤ 20 mmHg	≤ 20 mmHg	Flow dictated (usually < 15 mmHg)
Left atrium	Open	Open	Closed
Flow type	Continuous	Pulsatile	Continuous
Ventilation
Initial temperature	32 ^oC	34 ^oC	32 ^oC
Tidal volume	5-7 mL/kg	6 mL/kg	7 mL/kg
Respiratory rate	20/min	10/min	7/min
FiO₂	50%	12%	21%
PEEP	5 cmH₂O	5-7 cmH₂O	5 cmH₂O

FiO2: Fraction of inspired oxygen; RBCs: Red blood cells; PEEP: Positive end-expiratory pressure; OCS: Organ Care System.

Citation: Avtaar Singh SS, Das De S, Al-Adhami A, Singh R, Hopkins PM, Curry PA. Primary graft dysfunction following lung transplantation: From pathogenesis to future frontiers. World J Transplant 2023; 13(3): 58-85
URL: https://www.wjgnet.com/2220-3230/full/v13/i3/58.htm
DOI: https://dx.doi.org/10.5500/wjt.v13.i3.58

Avtaar Singh SS, Das De S, Al-Adhami A, Singh R, Hopkins PM, Curry PA. Primary graft dysfunction following lung transplantation: From pathogenesis to future frontiers. World J Transplant 2023; 13(3): 58-85 [PMID: 36968136 DOI: 10.5500/wjt.v13.i3.58]

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