Outcomes of total pancreatectomy with islet autotransplantation: A systematic review and meta-analysis

Table 4 Data summary of the included studies (continued)

Ref.	Pre-operative diabetes, n (%)	Alcohol induced pancreatitis, n (%)	Biliary tract disease, n (%)	Idiopathic pancreatitis, n (%)	Genetic mutation, n (%)	Pancreatic divism, n (%)	Autoimmune pancreatitis, n (%)	Post-operative narcotic independence, n (%)	Post-operative insulin independence, n (%)	Mean percent glycosylated hga1c, %, (SD), range
Adults
Argo et al[39]	Unknown	9 (35)	1 (4)	8 (31)	0	6 (23)	0	3 (60)	0 (0)
Najarian et al[30]	0 (0)	6 (60)	1 (10)	3 (30)	1 (10)1	0 (0)	0 (0)	7 (78)	4 (40) at range 1-38 mo
White et al[31]	0 (0)	8 (18)	2 (5)	13 (30)2	0 (0)	1 (2)	0 (0)	16 (77)	8 (33) transient/3 (13) at writing
Mokadem et al[32]	0 (0)	4 (7)	2 (4)	19 (63)	0 (0)	5 (17)	0 (0)	9 (16)	4 (15)
Garcae et al[24]	Unknown	19 (32)	5 (8)	31 (52)	0 (0)	0 (0)	0 (0)	27 (45)	11 (19)
Gruessner et al[33]	Unknown	7 (11)	0 (0)	45 (73)	10 (16)	0 (0)	0 (0)	43 (71)	12 (19) at range 1-24 mo
Fan et al[34]	Unknown	2 (10)	0 (0)	6 (30)	9 (45)	3 (15)	0 (0)	12 (60) at 6 mo	5 (25) at 12.5 mo	7.4 (0.5)
Wilson et al[15]	14 (13)	3 (3)	0 (0)	84 (75)	15 (13)	10 (9)	0 (0)	91 (55) at 1 yr /121 (73) at 5 yr	62 (38) at 1 yr/45 (27) at 5 yr	6.9 (0.3) 5.85-8.3
Sutherland et al[16]	32 (8)	27 (7)	36 (9)	169 (41)	58 (14)	71 (17)	0 (0)	241 (59) at 2 yr3	123 (30) at 3 yr4
Colling et al[35]	3 (5)	0 (0)	2 (3)	6 (10)	49 (83)	4 (7)	0 (0)	35 (66) at 1 yr	19 (32) at 1 yr
Toledo-Pereyra et al[40]	0 (0)	3 (50)	0 (0)	3 (50)	0 (0)	0 (0)	0 (0)		2 (50) at 20 and 25 mo
Ahmad et al[29]	1 (2)	2 (4)	0 (0)	39 (87)	1 (2)	8 (18)	0 (0)	23 (72) at 5 mo	18 (40) at mean 18 mo
Solomina et al[25]	Unknown	0 (0)	0 (0)	3 (15)	13 (65)	3 (15)	1 (5)	18 (87) at 1 yr	8 (53) at 1 yr
Wang et al[36]	11 (14)	Unknown	Unknown	Unknown	Unknown	Unknown	0 (0)	NA	31 (41) at 6 mo
Bellin et al[18]	2 (4)	0 (0)	13 (27)	18 (37)	4 (8)	11 (22)	0 (0)	22 (46) at 1 yr	21 (45) at 1 yr	6.0 (0.9) at 1 yr
Rabkin et al[37]	0 (0)	0 (0)	0 (0)	5 (100)	0 (0)	0 (0)	3 (60)	4 (80)	3 (60) at median 23 mo	6.43 (1.50) 5.1-8.0
Valente et al[41]	Unknown	Unknown	Unknown	Unknown	Unknown	Unknown	Unknown	Unknown	14 (64) at mean 5 yr
Rossi et al[38]	Unknown	2 (20)	0 (0)	8 (80)	0 (0)	1 (10)	0 (0)	9 (90)	7 (70) at 2 yr
Wahoff et al[50]	2 (4)	9 (19)	8 (16)	27 (56)	0 (0)	2 (4)	0 (0)	31 (81)	13 (34)
Garcea et al[51]	0 (0)	18 (36)	5 (10)	24 (48)	0 (0)	0 (0)	0 (0)	30 (59.8) at 1 yr
Pediatrics
Sutton et al[44]	0 (0)	0 (0)	0 (0)	0 (0)	16 (100)	0 (0)	0 (0)	10 (63) at mean 22 mo	4 (25) at mean 22 mo
Chinnakotla et al[17]	Unknown	0 (0)	0 (0)	21 (28)	41 (55)	0 (0)	0 (0)	13(17)	31 (41)
Bellin et al[18]	0 (0)	0 (0)	0 (0)	2 (12)	14 (82)	1 (6)	0 (0)	17 (100)	14 (82)
Bellin et al[52]	0 (0)	0(0)	1 (6)	7 (39)	7 (39)	3 (17)	0 (0)	11 (61) at median 2.5 (0.2-17.1)	11 (61) at 1 year or longer	6.40 (2.34) 5.0-12.5 at 4.5 (5.2); n = 8

¹Unconfirmed.

²Two identified as idiopathic/trauma.

³61% in pediatric patients.

⁴25% in adults, 55% in pediatric patients.

RC: Retrospective cohort; PCS: Prospective control study; CS: Case series; TPIAT: Total pancreatectomy with islet autotransplantation; NA: Not available.