Systematic Reviews
Copyright ©The Author(s) 2020.
World J Transplant. Mar 31, 2020; 10(3): 64-78
Published online Mar 31, 2020. doi: 10.5500/wjt.v10.i3.64
Table 3 Scaffold-based transplantation
Donor
Recipients (strain)OutcomesYear
ScaffoldSpeciesSeeding cell
Decellularized organ liverHumanMouse (C57BL/6J)Immunogenicity2015[2]
PorcineRat (F344)Immunogenicity2013[86]
PorcineImmunogenicity2013[87]
PorcineEngraftment2012[88]
Sheep, ratSheep, ratEngraftment2015[89]
RatHepatocytes (rat), BM- MSCs (Rat)Rat (Lewis)Engraftment2014[90]
Hepatocytes (rat)Rat (Lewis)Engraftment, Hepatic function2010[91], 2011[92]
MouseHematopoietic progenitor cells (mouse)Mouse (C57Bl/6)Hepatic function, metabolic function2018 [93]
BM-MSCs (mouse)Mouse (NOD-SCID)Survival extension, hepatic function2014[94]
PlacentaHumanLiver cells (sheep)SheepSurvival extension, hepatic function2018[15]
Amniotic membraneHumanAD-MSCs (human)MouseSurvival extension, hepatic function2015[95]
Nonwoven polyglycolic acid scaffoldsLiver cells (human, mouse)Mouse (NOD/SCID)Analysis of human metabolite2017[19]
3D hydrogelHepatocytes (human)Mouse (nude)Engraftment, hepatic function2016[16]
Hyaluronan tubeHepatocytes (rat), adipose-MSCs (human)Rat (nude)Engraftment, hepatic function2016[17]
Polyethylene glycol hydrogelsHepatocytes (rat)Mouse (Nude)Engraftment2015[20]
MicrobeadsHepatocytes (rat)Rat (SD)Hepatic function2014 [96]
Poly-L-glycolic acidHepatocytes (mouse)Mouse (NOD/SCID)Engraftment2014[21]
Hyaluronan hydrogelsHepatic stem cells (human)Mouse (Athymic nude)Engraftment2013[97]
Apatite-fiber scaffoldHepatocytes (mouse) + HSC + SECsMouse (BALB/CA nu)Hepatic function2011[98]
Chitosan-alginate fibrous scaffoldsBM-MSCs (human)Rat (Wistar)Hepatic function2010[99]
Hyaluronic acid spongeFetal hepatocyte (rat)Rat (LEC)Engraftment, hepatic function2010[18]