Taweesedt PT, Disthabanchong S. Mineral and bone disorder after kidney transplantation. World J Transplant 2015; 5(4): 231-242 [PMID: 26722650 DOI: 10.5500/wjt.v5.i4.231]
Corresponding Author of This Article
Sinee Disthabanchong, MD, Associate Professor of Medicine, Division of Nephrology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 270 Rama VI Rd, Phayathai, Bangkok 10400, Thailand. sineemd@hotmail.com
Research Domain of This Article
Urology & Nephrology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Transplant. Dec 24, 2015; 5(4): 231-242 Published online Dec 24, 2015. doi: 10.5500/wjt.v5.i4.231
Mineral and bone disorder after kidney transplantation
Pahnwat T Taweesedt, Sinee Disthabanchong
Pahnwat T Taweesedt, Sinee Disthabanchong, Division of Nephrology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand
Author contributions: Taweesedt PT and Disthabanchong S contributed equally to this review.
Conflict-of-interest statement: Authors declare no conflict of interests for this article
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Sinee Disthabanchong, MD, Associate Professor of Medicine, Division of Nephrology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 270 Rama VI Rd, Phayathai, Bangkok 10400, Thailand. sineemd@hotmail.com
Telephone: +66-2-2011116 Fax: +66-2-2011400
Received: June 25, 2015 Peer-review started: June 27, 2015 First decision: August 26, 2015 Revised: September 11, 2015 Accepted: October 23, 2015 Article in press: October 27, 2015 Published online: December 24, 2015
Core Tip
Core tip: Despite the improvement in mineral metabolites and mineral regulating hormones after kidney transplantation, abnormal mineral metabolism continues to present in most patients. High dose corticosteroid and persistent hyperparathyroidism are the most important factors influencing abnormal mineral metabolism in long-term kidney transplant recipients. The use of active vitamin D with or without bisphosphonate and steroid withdrawal regimen are effective in preventing early post-transplant bone loss. Calcimimetic is an alternative therapy to parathyroidectomy. If parathyroidectomy is required, subtotal to near total parathyroidectomy is recommended. Performing parathyroidectomy during the waiting period is also preferred in patients with severe hyperparathyroidism associated with hypercalcemia.
