Khullar V, Dolganiuc A, Firpi RJ. Pre-and-post transplant considerations in patients with nonalcoholic fatty liver disease. World J Transplant 2014; 4(2): 81-92 [PMID: 25032097 DOI: 10.5500/wjt.v4.i2.81]
Corresponding Author of This Article
Roberto J Firpi, MD, MS, AGAF, Department of Medicine, University of Florida College of Medicine, 1600 S.W. Archer Road, MSB-440, Gainesville, FL 32608, United States. roberto.firpi@medicine.ufl.edu
Research Domain of This Article
Transplantation
Article-Type of This Article
Review
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Transplant. Jun 24, 2014; 4(2): 81-92 Published online Jun 24, 2014. doi: 10.5500/wjt.v4.i2.81
Pre-and-post transplant considerations in patients with nonalcoholic fatty liver disease
Vikas Khullar, Angela Dolganiuc, Roberto J Firpi
Vikas Khullar, Angela Dolganiuc, Roberto J Firpi, Department of Medicine, University of Florida College of Medicine, Gainesville, FL 32608, United States
Roberto J Firpi, Section of Hepatobiliary Diseases and Transplantation, University of Florida College of Medicine, Gainesville, FL 32608, United States
Author contributions: Khullar V, Dolganiuc A and Firpi RJ solely contributed to this work.
Correspondence to: Roberto J Firpi, MD, MS, AGAF, Department of Medicine, University of Florida College of Medicine, 1600 S.W. Archer Road, MSB-440, Gainesville, FL 32608, United States. roberto.firpi@medicine.ufl.edu
Telephone: +1-352-2739466 Fax: +1-352-3927393
Received: November 27, 2013 Revised: February 17, 2014 Accepted: March 11, 2014 Published online: June 24, 2014
Core Tip
Core tip: Non-alcoholic fatty liver disease (NAFLD) is a major cause of chronic liver disease and one of the leading indication for liver transplantation (LT) nowadays. Although, it remains the third most common indication for LT in the United States, it is projected to become the most common indication by 2025. It presents a unique challenge for the transplant community in terms of management and long-term outcomes. Many risk factors for NAFLD pre-transplant such as obesity, hypertension, hyperlipidemia, diabetes continue to play an important role in the pathogenesis of post-transplant NAFLD. In addition to therapy focused on prevention and management of coexisting medical conditions, physicians must weight the benefits and harms of both medical and surgical options in patients undergoing LT.
