White matter alterations in anorexia nervosa: A systematic review of diffusion tensor imaging studies

Table 1 Baseline characteristics of the included studies (all cross-sectional in design)

Ref.	AN subtype	ED subtype	Study purpose	Method DTI	Assessment
Kazlouski et al[13]	Current AN restricting and purging subtype	AN purging and restricting subtype	Test of the brain WM integrity alteration and its relation to heightened anxiety in AN	GE 3 Tesla whole-body MRI scanner, maximum gradient amplitude of 40 Mt/M and maximum slew rate of 150 T/m per second, 8-channel phased-array head coil	SCID-CV
					EDI-3
					TCI
					STAI
					BDI
Frank et al[49]	Current AN restricting and purging subtype	AN	Analysis of GM and WM in a sample of adolescents in comparison to adults	Signa 3T Scanner, axial, 3-dimensional, T-1 weighted magnetization-prepared rapid acquisition gradient echo	C-DISC
					EDI-3
					TCI
					STAI
					CDI
					SPSRQ
					9 point Likert scale sweetness-pleasantness of 1 molar sucrose
Nagahara et al[7]	Current AN, NS subtype	AN	Exploration of WM abnormalities in AN patients compared to HC	Whole body 3 Tesla MR system with an eight-channel phased-array head coil	SCID-CV
					EDI-2
					BDI-II
Via et al[53]	Current AN restricting subtype	AN	Assessment of WM microstructure in a clinical sample of AN patients	GE Signa Excite scanner at 1.5 T equipped with an 8-channel phased-array head coil	SCID-CV
					SCID-I/NP
					GHQ-28
					EDI-2
					HAM-D
					HAM-A
Frieling et al[5]	Current AN with NS subtype and recovered women from AN	AN and recovered women from AN	Assessment of the microstructural integrity of WM pathways through DTI in women with AN	3 T Siemens-scanner, with a gradient field strength up to 45 MT/m	None
Yau et al[39]	Recovered women from restricting type AN	Recovered women from restricting type AN	Examination of the microstructural alterations of WM integrity in recovered AN women	3.0 Tesla Discovery MR750 scanner with an 8-channel phase-array head coil	SCID-CV
					MINI
					TCI
					STAI
					MPS

AN: Anorexia nervosa; DTI: Diffusion tensor imaging; GM: Gray matter; HC: Healthy controls; NS: Non-specified; WM: White matter.