Exosomal microRNAs in common mental disorders: Mechanisms, biomarker potential and therapeutic implications

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Aug 19, 2025 (publication date) through Aug 12, 2025

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Psychiatry. Aug 19, 2025; 15(8): 108933
Published online Aug 19, 2025. doi: 10.5498/wjp.v15.i8.108933

Table 6 Summary of changes of exosomal microRNAs in bipolar disorder

miRNAs	Alteration	Model	Type tissue	Significance	Ref.
miR-484, miR-652-3p, miR-142-3p	Decrease	BD human patients	Plasma	Abnormally regulated miRNAs enrich multiple target pathways, including the PI3K/Akt signaling pathway, fatty acid biosynthesis/metabolism, and extracellular matrix	Ceylan et al[103]
miR-185-5p	Increase	BD human patients	Plasma	Regulate the adhesion pathway	Ceylan et al[103]

miRNA: MicroRNA; PI3K: Phosphatidylinositol 3-kinase; Akt: Protein kinase B; BD: Bipolar disorder.

Citation: He YN, Zhu HH, Zhou ZH, Qu KK. Exosomal microRNAs in common mental disorders: Mechanisms, biomarker potential and therapeutic implications. World J Psychiatry 2025; 15(8): 108933
URL: https://www.wjgnet.com/2220-3206/full/v15/i8/108933.htm
DOI: https://dx.doi.org/10.5498/wjp.v15.i8.108933