Exosomal microRNAs in common mental disorders: Mechanisms, biomarker potential and therapeutic implications

Table 4 Summary of changes of exosomal microRNAs in schizophrenia patients

miRNAs	Alteration	Model	Type tissue	Significance	Ref.
miR-203a-3p	Increase	Human patients, cells	Blood sample, cell	Targeted regulation of the 3’UTRs of DJ-1. Possible therapeutic target for schizophrenia	Tsoporis et al[91]
miR-675-3p		Human patients, cell models	Peripheral blood, cell	Associated with clozapine therapy. Understanding new pathogenesis	Funahashi et al[92]
miR-486-5p, miR-199a-3p, miR-144-5p, miR-451a, miR-143-3p, miR-142- 3p	Decrease	Human patients	Urine	Urinary exosomal miRNA is a biomarker for predicting schizophrenia	Tomita et al[93]

miRNA: MicroRNA; 3’UTR: 3’untranslated region.