Exosomal microRNAs in common mental disorders: Mechanisms, biomarker potential and therapeutic implications

Table 3 Summary of changes of exosomal microRNAs in schizophrenia related animal experiments

miRNAs	Alteration	Model	Type tissue	Significance	Ref.
miR-137	Increase	Gclm-KO mice, human patients	Plasma, prefrontal cortex	The changes in the level of miR-137/COX6A2 in plasma exosomes may be a marker of schizophrenia caused by PVI injury resulting from mitochondrial oxidative stress	Khadimallah et al[49]
miR-146a-5p	Increase	Schizophrenia mouse models, cell models	Plasma, cell	It may target NOTCH1, inhibit synaptic activity mediated by the Notch signaling pathway, and ultimately promote the occurrence and progression of schizophrenia in mice	Wang et al[89]
miR-223-3p	Increase	Mouse models, human postmortem brain, cell models	Cortical neuron, postmortem brain, astrocyte	miR-223 is a miRNA secreted by exosomes targeting glutamate receptors	Amoah et al[90]

miRNA: MicroRNA; PVI: Parvalbumin interneurons.