Increased expression of the neuroplastin 65 protein is involved in neurofibrillary tangles and amyloid beta plaques in Alzheimer’s disease

Figure 3 Expression of neuroplastin 65 immunoreactivity in human lentiform nucleus, midbrain and pons. A: A representative immunohistochemical staining micrograph in the lentiform nucleus, with an inset indicating the position of the sampling (scale bars = 5 mm); B: A representative immunohistochemical staining micrograph in the lentiform nucleus, with an inset indicating the position of the sampling (higher power views, scale bars = 200 μm). Note that neuroplastin 65 immunoreactivity shows strong punctate staining in the putamen, while there are dense networks in the globus pallidus; C: An immunohistochemical staining micrograph in the midbrain at a low magnification view, with an inset indicating the position of the sampling (scale bars = 5 mm); D: An immunohistochemical staining micrograph in the midbrain at a low magnification view, with an inset indicating the position of the sampling (higher power view, scale bars = 200 μm). Note that there is positive punctate staining and fibers in the substantia nigra and less intense positive fibers in the red nucleus; E: A low magnification view of the pons, with an inset indicating the position of the sampling (scale bars = 5 mm); F: A low magnification view of the pons, with an inset indicating the position of the sampling (higher power views, scale bars = 200 μm). The nucleus is stained by hematoxylin. iCtx: Insular cortex; Pu: Putamen; GPe: External part of the globus pallidus; GPi: Internal part of the globus pallidus; IC: Internal capsule; CC: Crus cerebri; SN: Substantia nigra; RN: Red nucleus; SC: Superior colliculus; RF: Reticular formation; BPP: Basilar part of the pons; TP: Tegmentum of the pons; PT: Pyramidal tract; CT: Corticopontine tract; MCP: Middle cerebellar peduncle.