Increased expression of the neuroplastin 65 protein is involved in neurofibrillary tangles and amyloid beta plaques in Alzheimer’s disease

Figure 1 Expression and cellular localization of neuroplastin 65 immunoreactivity in human hippocampal formation. A: Neuroplastin 65 (NP65) immunofluorescent staining in a coronal section of the human hippocampal formation. A representative view of the human hippocampal formation at a low magnification (scale bars = 3 mm); B and C: NP65 immunofluorescent staining in a coronal section of the human hippocampal formation. Representative micrographs of NP65 immunoreactivity in the cornu ammonis 1 (CA1) region and dentate gyrus at a high magnification view. Note the immunoreactive knots (indicated by an arrow) in the stratum granulosum; D and E: Quantification of NP65 immunofluorescent staining in the sublayers of CA1 and DG and hippocampal areas; F: A representative scan of the human hippocampal formation (scale bars = 3 mm); G and H: Representative micrographs of NP65 immunoreactivity in the CA1 region and dentate gyrus at a high magnification view. Note the immunoreactive knots (indicated by an arrow) in the stratum granulosum; I: Quantification of NP65 immunohistochemical staining in hippocampal areas. DG: Dentate gyrus; CA: Cornu ammonis; HIL: Hilus; SUB: Subiculum; EC: Entorhinal cortex; SG: Stratum granulosum; SM: Stratum moleculare; SPl: Stratum plexiforme; SLM: Stratum lacunosum-molecular; SR: Stratum radiatum; SP: Stratum pyramidale; SO: Stratum oriens.