Predictors of poor prognosis in long-term survivors of differentiated thyroid cancer with psychiatric disorders

Table 2 Comparison of clinical features of thyroid cancer patients with different prognoses, mean ± SD/n (%)

Clinical feature	Total number of patients (n = 48)	Good prognosis group (n = 38)	Poor prognosis group (n = 10)	χ2/t	P value
Age (years)	56.67 ± 6.25	57.21 ± 6.17	54.60 ± 6.47	1.179	0.245
Gender				0.254	0.614
Male	23 (47.92)	17 (44.74)	6 (60.00)
Female	25 (52.08)	21 (55.26)	4 (40.00)
BMI (kg/m2)	23.11 ± 3.57	22.92 ± 3.50	23.81 ± 3.95	0.697	0.489
Tumour duration (months)	18.15 ± 2.32	18.34 ± 2.13	17.40 ± 2.84	1.157	0.253
Incidence side				1.044	0.307
Unilateral	37 (77.08)	31 (81.58)	6 (60.00)
Bilateral	11 (22.92)	7 (18.42)	4 (40.00)
Pathological type				2.695	0.101
Papillocarcinoma	36 (75.00)	31 (81.58)	5 (50.00)
Lecarcinome folliculaire	12 (25.00)	7 (18.42)	5 (50.00)
Number of lesions				0.393	0.531
Single	21 (43.75)	18 (47.37)	3 (30.00)
Multiple	27 (56.25)	20 (52.63)	7 (70.00)
Tumour diameter (cm)	2.71 ± 0.84	2.48 ± 0.73	3.62 ± 0.62	4.519	0.000
T stage				5.013	0.025
T1-T2	27 (56.25)	25 (65.79)	2 (20.00)
T3-T4	21 (43.75)	13 (34.21)	8 (80.00)
Lymph node metastasis	42 (87.50)	34 (89.47)	8 (80.00)	0.072	0.788
Extra-glandular infiltration	6 (12.50)	1 (2.63)	5 (50.00)	12.199	0.001
Degree of differentiation				8.181	0.004
Moderate-high differentiation	43 (89.58)	37 (97.37)	6 (60.00)
Low differentiation	5 (10.42)	1 (2.63)	4 (40.00)
FT3 (pmol/L)	18.96 ± 2.54	18.04 ± 1.86	22.45 ± 1.47	6.931	0.000
FT4 (pmol/L)	52.23 ± 18.41	46.77 ± 15.04	72.96 ± 15.42	4.875	0.000
TSH (mU/L)	2.96 ± 0.46	2.97 ± 0.48	2.95 ± 0.42	0.120	0.905
TT3 (nmol/L)	2.03 ± 0.24	2.03 ± 0.27	2.06 ± 0.14	0.338	0.737
TT4 (nmol/L)	106.33 ± 22.41	106.98 ± 21.54	103.82 ± 26.61	0.393	0.696
ALT (U/L)	32.65 ± 11.52	29.57 ± 10.15	44.37 ± 8.73	4.211	0.000
AST (U/L)	28.13 ± 5.65	27.79 ± 5.74	29.40 ± 5.43	0.797	0.429
ALP (U/L)	87.15 ± 21.74	86.58 ± 23.42	89.34 ± 14.38	0.354	0.725
TBil (μmol/L)	18.13 ± 5.58	16.34 ± 4.49	24.90 ± 3.96	5.485	0.000
TP (g/L)	73.26 ± 6.35	72.34 ± 6.08	76.79 ± 6.41	2.037	0.047
ALB (g/L)	41.54 ± 6.94	43.51 ± 6.07	34.06 ± 4.60	4.575	0.000
Cortisol (nmol/L)	198.41 ± 16.98	193.77 ± 15.47	216.07 ± 9.09	4.344	0.000
NE (ng/L)	326.85 ± 56.31	309.14 ± 43.96	394.17 ± 47.51	5.355	0.000
Ang II (ng/mL)	23.68 ± 4.98	22.22 ± 4.47	29.25 ± 1.92	4.827	0.000
SOD (nU/mL)	76.25 ± 6.21	78.35 ± 4.59	68.31 ± 5.13	6.010	0.000

BMI: Body mass index; FT3: Serum free T3; FT4: Serum free T4; TSH: Thyroid stimulating hormone; TT3: Total triiodothyronine; TT4: Total thyroxine; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALP: Alkaline phosphatase; TBil: Total bilirubin; TP: Total protein; ALB: Albumin; NE: Norepinephrine; Ang II: Angiotensin II; SOD: Superoxide dismutase.