Predictors of poor prognosis in long-term survivors of differentiated thyroid cancer with psychiatric disorders

Table 1 Comparison of clinical features of patients in different groups, mean ± SD/n (%)

Clinical feature	Total number of patients (n = 108)	Thyroid cancer group (n = 48)	Benign nodule group (n = 30)	Mental disorder group (n = 30)	χ2/F	P value
Age (years)	56.27 ± 6.51	56.67 ± 6.25	56.17 ± 7.06	55.76 ± 6.58	0.183	0.833
Gender					0.158	0.924
Male	50 (46.30)	23 (47.92)	13 (43.33)	14 (46.67)
Female	58 (53.70)	25 (52.08)	17 (56.67)	16 (53.33)
BMI (kg/m2)	23.21 ± 3.48	23.11 ± 3.57	23.26 ± 3.62	23.35 ± 3.29	0.046	0.955
Smoking history	24 (22.22)	14 (29.17)	6 (20.00)	4 (13.33)	2.796	0.247
Drinking history	32 (29.63)	19 (39.58)	7 (23.33)	6 (20.00)	4.185	0.123
Duration of mental disorders (years)	3.48 ± 0.62	3.54 ± 0.21	3.49 ± 0.32	3.41 ± 0.24	2.440	0.092
FT3 (pmol/L)	16.20 ± 4.66	18.96 ± 2.54	16.25 ± 5.33	11.75 ± 2.85	36.979	0.000
FT4 (pmol/L)	38.87 ± 20.20	52.23 ± 18.41	39.52 ± 12.33	16.85 ± 2.65	59.105	0.000
TSH (mU/L)	2.94 ± 0.47	2.96 ± 0.46	2.89 ± 0.54	2.94 ± 0.41	0.206	0.814
TT3 (nmol/L)	2.04 ± 0.28	2.03 ± 0.24	2.05 ± 0.28	2.04 ± 0.19	0.065	0.937
TT4 (nmol/L)	107.58 ± 21.31	106.33 ± 22.41	111.31 ± 19.63	105.85 ± 21.36	0.637	0.531
ALT (U/L)	27.73 ± 10.81	32.65 ± 11.52	28.45 ± 7.69	19.13 ± 6.34	19.555	0.000
AST (U/L)	27.75 ± 5.38	28.13 ± 5.65	27.95 ± 4.98	26.95 ± 5.41	0.468	0.628
ALP (U/L)	84.27 ± 22.42	87.15 ± 21.74	84.96 ± 22.14	78.98 ± 23.54	1.252	0.290
TBil (μmol/L)	15.86 ± 5.69	18.13 ± 5.58	16.23 ± 4.16	11.85 ± 5.11	14.151	0.000
TP (g/L)	72.76 ± 5.76	73.26 ± 6.35	72.99 ± 5.18	71.72 ± 5.34	0.691	0.504
ALB (g/L)	43.22 ± 5.84	41.54 ± 6.94	43.79 ± 5.29	45.33 ± 3.18	4.345	0.015
Cortisol (nmol/L)	178.77 ± 28.43	198.41 ± 16.98	179.87 ± 14.13	146.23 ± 24.11	72.976	0.000
NE (ng/L)	277.50 ± 69.03	326.85 ± 56.31	249.85 ± 44.18	226.17 ± 54.25	39.491	0.000
Ang II (ng/mL)	18.89 ± 5.84	23.68 ± 4.98	15.79 ± 2.54	14.32 ± 3.15	64.523	0.000
SOD (nU/mL)	92.99 ± 22.98	76.25 ± 6.21	95.34 ± 6.41	117.41 ± 27.54	66.166	0.000

BMI: Body mass index; FT3: Serum free T3; FT4: Serum free T4; TSH: Thyroid stimulating hormone; TT3: Total triiodothyronine; TT4: Total thyroxine; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALP: Alkaline phosphatase; TBil: Total bilirubin; TP: Total protein; ALB: Albumin; NE: Norepinephrine; Ang II: Angiotensin II; SOD: Superoxide dismutase.