Magnesium-L-threonate exhibited a neuroprotective effect against oxidative stress damage in HT22 cells and Alzheimer’s disease mouse model

Figure 7 Magnesium-L-threonate administration regulated the neuronal apoptosis and mediated the expression of apoptotic-related proteins in APPswe/PS1dE9 mouse hippocampus. A, B: The apoptosis rate of hippocampal neuron of each group; C: Protein band images of B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X (Bax) and glyceraldehyde-3-phosphate dehydrogenase of each group; D: The Bcl-2 protein expression level of each group; E: The Bax protein expression level of each group. n = 3. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001 vs former group. MgT: Magnesium-L-threonate; TG: APPswe/PS1dE9 mice group; WT: Wild-type mice group; Bcl-2: B-cell lymphoma 2; Bax: Bcl-2-associated X; GAPDH: glyceraldehyde-3-phosphate dehydrogenase.