Magnesium-L-threonate exhibited a neuroprotective effect against oxidative stress damage in HT22 cells and Alzheimer’s disease mouse model

Figure 4 Magnesium-L-threonate treatment suppressed the downregulation of phosphatidylinositol-3-kinase/protein kinase B pathway in the amyloid β_25-35-exposed HT22 cells. A: Protein band images of phosphorylated (p)-phosphatidylinositol-3-kinase (PI3K), PI3K, p-protein kinase B (Akt), Akt and glyceraldehyde-3-phosphate dehydrogenase of each group; B: The p-PI3K/PI3K ratio of each group; C: The p-Akt/Akt ratio of each group. n = 3. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001 vs former group. Aβ: Amyloid β; MgT: Magnesium-L-threonate; PI3K: phosphatidylinositol-3-kinase; Akt: protein kinase B; GAPDH: glyceraldehyde-3-phosphate dehydrogenase.