How to construct neuroscience-informed psychiatric classification? Towards nomothetic networks psychiatry

Figure 1 A causal theoretical model applicable to mood and psychotic disorders. This model links causome features (genes and gene products and environmentome factors) with adverse outcome pathways (AOP) and the phenome of the illness. The phenome consists of brainome and cognitome factors and adverse health outcomes including in the symptomatome and the phenomenome. Moreover, staging of illness may partly mediate the effects of risk/resilience and AOPs on the phenome. Age, sex, body mass index, metabolic syndrome, tobacco use disorder, and psychiatric and medical comorbidities are frequent moderators of the effects of R/R and AOPs on the phenome. AOP: Adverse outcome pathway; AOH: Adverse health outcome; MetS: Metabolic syndrome; BMI: Body mass index.