Identification of key genes involved in post-traumatic stress disorder: Evidence from bioinformatics analysis

Table 1 Gene ontology annotations of differentially expressed genes associated with post-traumatic stress disorder (top 5)

Expression	Category	Term	Function	Count	P value
Up-regulated	BP	GO: 0007399	Nervous system development	25	1.21E–08
	BP	GO: 0007409	Axonogenesis	14	1.82E–08
	BP	GO: 0007268	Chemical synaptic transmission	16	1.33E–07
	BP	GO: 0030154	Cell differentiation	32	3.75E–06
	BP	GO: 0010976	Positive regulation of neuron projection development	12	1.51E–05
	CC	GO: 0045202	Synapse	43	1.25E–18
	CC	GO: 0043025	Neuronal cell body	39	1.18E–14
	CC	GO: 0030425	Dendrite	37	2.35E–14
	CC	GO: 0030054	Cell junction	44	7.70E–14
	CC	GO: 0030424	Axon	31	3.10E–13
	MF	GO: 0005515	Protein binding	99	3.15E–05
	MF	GO: 0050839	Cell adhesion molecule binding	8	1.71E–04
	MF	GO: 0019904	Protein domain specific binding	15	3.48E–04
	MF	GO: 0005216	Ion channel activity	11	5.51E–04
	MF	GO: 0008144	Drug binding	8	0.002625
Down-regulated	BP	GO: 0015031	Protein transport	38	7.01E–06
	BP	GO: 0007049	Cell cycle	38	1.59E–05
	BP	GO: 0016192	Vesicle-mediated transport	17	4.14E–04
	BP	GO: 0007040	Lysosome organization	7	7.61E–04
	BP	GO: 0006281	DNA repair	21	8.39E–04
	CC	GO: 0005737	Cytoplasm	243	1.19E–08
	CC	GO: 0005634	Nucleus	219	2.55E–07
	CC	GO: 0005829	Cytosol	77	5.42E–05
	CC	GO: 0005768	Endosome	30	4.60E–04
	CC	GO: 0005794	Golgi apparatus	53	4.91E–04
	MF	GO: 0046872	Metal ion binding	135	4.24E–06
	MF	GO: 0005515	Protein binding	156	1.17E–05
	MF	GO: 0003676	Nucleic acid binding	61	1.93E–05
	MF	GO: 0005487	Nucleocytoplasmic transporter activity	5	0.001069
	MF	GO: 0016874	Ligase activity	22	0.001335

BP: Biological processes; CC: Cellular component; MF: Molecular function; GO: Gene ontology.