Clinical and Translational Research
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Jan 19, 2024; 14(1): 15-25
Published online Jan 19, 2024. doi: 10.5498/wjp.v14.i1.15
Association between inflammatory bowel disease and all-cause dementia: A two-sample Mendelian randomization study
Ou-Lan Liao, Si-Yuan Xie, Jun Ye, Qin Du, Guo-Chun Lou
Ou-Lan Liao, Si-Yuan Xie, Jun Ye, Qin Du, Guo-Chun Lou, Department of Gastroenterology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China
Ou-Lan Liao, Qin Du, Department of Gastroenterology, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu 322000, Zhejiang Province, China
Co-corresponding authors: Qin Du and Guo-Chun Lou.
Author contributions: Liao OL designed the study, acquired and analyzed data, and wrote the manuscript; Xie SY contributed to conceptualization and methodology; Ye J contributed to writing review and editing; Du Q and Lou GC designed, refined the study protocol, and supervised this study. All authors were involved in the critical review of the results and have contributed to, read, and approved the final manuscript. Du Q and Lou GC contributed equally to this work as co-corresponding authors. Firstly, both researchers were co-principal investigators of this study and have made equally significant contributions throughout the study process. Designating them as co-corresponding authors accurately reflects the allocation of responsibilities related to completing the study. Secondly, both researchers shared responsibility for ensuring the authenticity of the manuscript's content and credibility of its conclusions, as well as handling communication and consultation work. Therefore, we believe that designating Du Q and Lou GC as co-corresponding authors is appropriate, reflecting the collaborative spirit and equal contributions of our team.
Institutional review board statement: No institutional review board statement is required since this study was based on public databases.
Clinical trial registration statement: The data was from large sample size GWAS, and no Clinical Trial Registration Statement is required.
Informed consent statement: The data was from large sample size genome-wide association study, and no informed consent statement is required.
Conflict-of-interest statement: The authors have no conflict of interest to report.
Data sharing statement: The summary statistics of IBD, UC, and CD GWAS (IIBDGC) is available at https://gwas.mrcieu.ac.uk/datasets/ieu-a-31, https://gwas.mrcieu.ac.uk/datasets/ieu-a-32, and https://gwas.mrcieu.ac.uk/datasets/ieu-a-30, respectively. The summary data for the second IBD GWAS (UK Biobank) is provided at https://cnsgenomics.com/data/wu_et_al_2021_nc/5_IBD_summary. The summary statistics of all-cause dementia, dementia in AD, VaD, dementia in other diseases classified elsewhere, and unspecified dementia GWAS (FinnGen) is available at https://storage.googleapis.com/finngen-public-data-r7/summary_stats/finngen_R7_F5_DEMENTIA.gz, https://storage.googleapis.com/finngen-public-data-r7/summary_stats/finngen_R7_F5_ALZHDEMENT.gz, https://storage.googleapis.com/finngen-public-data-r7/summary_stats/finngen_R7_F5_VASCDEM.gz, https://storage.googleapis.com/finngen-public-data-r7/summary_stats/finngen_R7_F5_DEMINOTH.gz, and https://storage.googleapis.com/finngen-public-data-r7/summary_stats/finngen_R7_F5_DEMNAS.gz, respectively. All datasets were downloaded on 2023-7-11.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qin Du, MBBS, Chief Physician, Department of Gastroenterology, The Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88 Jiefang Road, Hangzhou 310009, Zhejiang Province, China. duqin@zju.edu.cn
Received: November 7, 2023
Peer-review started: November 7, 2023
First decision: November 23, 2023
Revised: December 3, 2023
Accepted: December 26, 2023
Article in press: December 26, 2023
Published online: January 19, 2024
Core Tip

Core Tip: Dementia is a major disease burden for public health and healthcare systems worldwide. This study used two-sample Mendelian randomization (MR) to assess the causal relationship between inflammatory bowel disease (IBD) and all-cause dementia. Multiple MR methods have failed to find that IBD increases the risk of developing all-cause dementia and its four subtypes. The present study suggests that genetically predicted IBD is not associated with risk of all-cause dementia and that dementia prevention interventions for patients with IBD can be similar to those for the healthy population.