Observational Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Jan 19, 2024; 14(1): 128-140
Published online Jan 19, 2024. doi: 10.5498/wjp.v14.i1.128
Abnormalities of electroencephalography microstates in patients with depression and their association with cognitive function
Rui-Jie Peng, Yu Fan, Jin Li, Feng Zhu, Qing Tian, Xiao-Bin Zhang
Rui-Jie Peng, Suzhou Medical College, Soochow University, Suzhou 215123, Jiangsu Province, China
Yu Fan, Jin Li, Feng Zhu, Qing Tian, Xiao-Bin Zhang, Department of Psychiatry, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou 215137, Jiangsu Province, China
Co-first authors: Rui-Jie Peng and Yu Fan.
Co-corresponding authors: Qing Tian and Xiao-Bin Zhang.
Author contributions: Peng RJ and Fan Y were responsible for data collection, data curation, and writing original draft; Li J and Zhu F were involved in supervision and review; Tian Q and Zhang XB as co-corresponding author, participated in conceptualization, funding acquisition, supervision and editing; all authors reviewed the manuscript.
Supported by Suzhou Key Technologies Program, No. SKY2021063; Suzhou Clinical Medical Center for Mood Disorders, No. Szlcyxzx202109; Suzhou Clinical Key Disciplines for Geriatric Psychiatry, No. SZXK202116; Jiangsu Province Social Development Project, No. BE2020764; the Gusu Health Talents Project, No. GSWS2022091; the Science and Technology Program of Suzhou, No. SKYD2022039 and No. SKY2023075; and the Doctoral Scientific Research Foundation of Suzhou Guangji Hospital, No. 2023B01.
Institutional review board statement: The study was reviewed and approved by the Ethics Committee of Suzhou Guangji Hospital Institutional Review Board, Approval No. 2020008.
Informed consent statement: All clinical trials were obtained informed consent.
Conflict-of-interest statement: No conflict of interest was disclosed for each author.
Data sharing statement: The data are available from the corresponding author on reasonable request.
STROBE statement: The authors have read the STROBE Statement, and the manuscript was prepared and revised according to the STROBE Statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Bin Zhang, MD, PhD, Chief Physician, Department of Psychiatry, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, No. 11 Guangqian Road, Suzhou 215137, Jiangsu Province, China. zhangxiaobim@163.com
Received: September 29, 2023
Peer-review started: September 29, 2023
First decision: November 2, 2023
Revised: November 9, 2023
Accepted: December 22, 2023
Article in press: December 22, 2023
Published online: January 19, 2024
Core Tip

Core Tip: This study aims to explore electroencephalography microstates in patients with depression and the correlation between microstates and cognitive scales. Through statistical analyses, we found parameters of the microstate C were higher while microstate D were lower in patients with depression compared with the controls. A positive correlation was observed between the visuospatial/constructional scores and the transition probability of microstate C to B. Therefore, we speculate that microstates C and D, is a possible biomarker in depression. Patients with depression had a more frequent transition from microstate C to B, which may relate to more negative rumination and visual processing.