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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Jun 19, 2022; 12(6): 827-842
Published online Jun 19, 2022. doi: 10.5498/wjp.v12.i6.827
Published online Jun 19, 2022. doi: 10.5498/wjp.v12.i6.827
Disrupted leptin-fatty acid biosynthesis is an early manifestation of metabolic abnormalities in schizophrenia
Mohammad M Khan, Laboratory of Translational Neurology and Molecular Psychiatry, Department of Biotechnology, Era's Lucknow Medical College and Hospital, and Faculty of Science, Era University, Lucknow 226003, India
Mohammad M Khan, Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta University, Augusta, GA 30912, United States
Author contributions: Khan MM Designed and performed the research, and wrote the paper.
Institutional review board statement: Institutional Review Boards of DDEAMC and MCG, Augusta, GA approved the research protocol.
Informed consent statement: A signed consent was taken from all the patients and CNT subjects.
Conflict-of-interest statement: Authors declare no conflict of interest.
STROBE statement: The authors have read the STROBE statement, and the manuscript was prepared and revised according to the STROBE statement.
Data sharing statement: No data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mohammad M Khan, PhD, Professor, Laboratory of Translational Neurology and Molecular Psychiatry, Department of Biotechnology, Era's Lucknow Medical College and Hospital, and Faculty of Science, Era University, Sarfarazganj, Hardoi Road, Lucknow 226003, India. mmkhan0@gmail.com
Received: December 31, 2021
Peer-review started: December 31, 2021
First decision: March 13, 2022
Revised: April 3, 2022
Accepted: May 22, 2022
Article in press: May 22, 2022
Published online: June 19, 2022
Peer-review started: December 31, 2021
First decision: March 13, 2022
Revised: April 3, 2022
Accepted: May 22, 2022
Article in press: May 22, 2022
Published online: June 19, 2022
Core Tip
Core Tip: Insulin resistance (IR) and impaired energy expenditure (IEE) are untreatable metabolic comorbidities in schizophrenia. Leptin and fatty acids have profound influence on insulin synthesis, secretion and energy metabolism. Although previous studies have measured plasma leptin and membrane fatty acids in schizophrenia, findings are very heterogeneous, and moreover, no single study has ever measured both plasma leptin and membrane fatty acids together in the same cohort of schizophrenia patients. These studies are crucial not only for analyzing the relationship between leptin and fatty acids in the same cohort of schizophrenia patients, but also for deciphering their role in the development of IR and IEE.