Observational Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Mar 19, 2024; 14(3): 409-420
Published online Mar 19, 2024. doi: 10.5498/wjp.v14.i3.409
Mediating role of social support in dysphoria, despondency, and quality of life in patients undergoing maintenance hemodialysis
Xiang Zhou, Hong Jiang, Yi-Peng Zhou, Xiao-Yu Wang, Hai-Yan Ren, Xue-Fei Tian, Qing-Qing Zhang
Xiang Zhou, Hong Jiang, Yi-Peng Zhou, Xiao-Yu Wang, Qing-Qing Zhang, Department of Nephrology, People’s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Clinical Research Center for Kidney Disease, Urumqi 832000, Xinjiang Uygur Autonomous Region, China
Hai-Yan Ren, Department of Endocrinology and Metabolism, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 832000, Xinjiang Uygur Autonomous Region, China
Xue-Fei Tian, Section of Nephrology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, United States
Author contributions: Zhou X designed and performed the research and wrote the paper; Zhou YP designed the research and supervised the report; Wang XY and Hong J designed the research and contributed to the analysis; Ren HY and Tian XF designed the research and provided clinical advice; Zhang QQ designed the research and supervised the report; All authors approved the final manuscript.
Supported by the Natural Science Foundation Project of Xinjiang Uygur Autonomous Region, No. 2021D01C143.
Institutional review board statement: The study was reviewed and approved by the People’s Hospital of Xinjiang Uygur Autonomous Region.
Informed consent statement: All study participants, or their legal guardians, provided informed written consent before study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The data used in this study can be obtained from the corresponding author upon request at qingqigzhang@163.com.
STROBE statement: The authors have read the STROBE Statement – checklist of items, and the manuscript was prepared and revised according to the STROBE Statement – checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qing-Qing Zhang, MBBS, Associate Chief Nurse, Department of Nephrology, People’s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Clinical Research Center for Kidney Disease, No. 91, Tianchi Road, Tianshan District, Urumqi 832000, Xinjiang Uygur Autonomous Region, China. qingqigzhang@163.com
Received: November 30, 2023
Peer-review started: November 30, 2023
First decision: December 18, 2023
Revised: December 30, 2023
Accepted: January 23, 2024
Article in press: January 18, 2024
Published online: March 19, 2024
ARTICLE HIGHLIGHTS
Research background

Patients undergoing Maintenance Hemodialysis (MHD) frequently experience dysphoria and despondency during extended dialysis treatment. These psychological difficulties can lead to alterations in daily routines, a decline in physical capabilities, a loss of social roles and status, and a profound influence on physical and mental well-being, along with overall quality of life (QOL). Consequently, enhancing their QOL is of the utmost importance.

Research motivation

Dysphoria and despondency can significantly diminish the QOL of patients undergoing MHD, whereas strong social support can enhance it. This study investigated the role of social support as a mediator between dysphoria, despondency, and QOL in patients undergoing MHD. This study aimed to establish a theoretical foundation for psychological interventions among patients undergoing MHD, enabling the implementation of effective strategies to boost social support levels and enhance their overall QOL.

Research objectives

The primary objective of this study was to investigate the influence of social support on dysphoria, despondency, and QOL in patients undergoing MHD. Additionally, it aimed to assess the mediating role of social support by constructing a mediating effect model that incorporated social support, dysphoria, despondency, and QOL. The ultimate goal was to enhance the level of social support for patients undergoing MHD, thereby mitigating the effects of dysphoria and despondency and ultimately improving their overall QOL.

Research methods

This cross-sectional study included 289 patients from our hospital. The Social support rating scale, Self-rating anxiety scale, Self-rating depression scale, and Life quality scale were used to collect data. Correlation analysis was used to examine the associations between social support, dysphoria, despondency, and the QOL in patients undergoing MHD. Furthermore, the bootstrap method was employed to assess the mediating effect of social support on the relationships among dysphoria, despondency, and QOL in these patients.

Research results

The study revealed several key findings: (1) Social support was positively correlated with QOL and negatively correlated with dysphoria and despondency; (2) Dysphoria and despondency had a negative impact on the QOL of patients undergoing maintenance hemodialysis; (3) The negative impact of dysphoria and despondency on QOL decreased in the presence of social support; and (4) Social support played a significant mediating role in the relationship between dysphoria, despondency, and QOL. These findings provide valuable insights for healthcare professionals and offer a basis for the targeted treatment and improved care of patients undergoing MHD.

Research conclusions

This study demonstrated that social support plays a mediating role in the relationship between dysphoria, despondency, and QOL in patients undergoing MHD. This study addressed the gap in the understanding of how social support influences the interplay between dysphoria, despondency, and QOL in patients undergoing MHD, providing a valuable theoretical foundation for future studies in this area.

Research perspectives

Future research in this area should consider expanding the sample size and incorporating multi-regional samples to gain a more comprehensive understanding of the relationships among social support, dysphoria, despondency, and QOL in patients undergoing MHD. Additionally, longitudinal studies could provide valuable insights into the evolution of these factors over time in patients undergoing MHD.