Review
Copyright ©The Author(s) 2015.
World J Pharmacol. Mar 9, 2015; 4(1): 47-57
Published online Mar 9, 2015. doi: 10.5497/wjp.v4.i1.47
Table 1 Classification of the most commonly used human breast cancer cell lines
NameHistopathologicalclassificationImmunohistochemicalclassification
MCF-7Luminal AER+, PR+, Her2-
SUM185Luminal AER+, PR-, Her2-
T47DLuminal AER+, PR+, Her2-
BT-474Luminal BER+, PR+, Her2+
ZR-75Luminal BER+, PR-, Her2+
SKBR3Her2-positiveER-, PR-, Her2+
MDA-MB-453Her2-positiveER-, PR-, Her2+
MDA-MB-468BasalER-, PR-, Her2-
SUM190BasalER-, PR-, Her2+
BT-20BasalER-, PR-, Her2-
MDA-MB-231Claudin-lowER-, PR-, Her2-
HS-578TClaudin-lowER-, PR-, Her2-
Cal-51Claudin-lowER-, PR-, Her2-
Table 2 Classification of the most commonly used human prostate cancer cell lines
NameSite of originHormonal statusPSA expression
PC-3BoneAR-No
DU-145BrainAR-No
LNCaPLymph nodeASYes
C4-2BSubline of LNCaPAIYes
VCaPBoneASYes
CWR22ProstateASYes
22Rv1Subline of 22Rv1AIYes
PC-346ProstateASYes
Table 3 Comparison of different types of breast and prostate cancer xenograft models
TypeRelevant MEMetastasesCostsEaseRef.
SubcutaneousNoNoLowEasy[51]
Orthotopic BrCaYesYesLowEasy[45]
Orthotopic PCaYesYesMediumDifficult[55]
IntratibialYesYesMediumDifficult[56]
Intravenous/cardiacYesYesMediumMedium[60]
HumanizedYesYesHighDifficult[67]
PDXYesNoHighDifficult[94]