Kv7 channels a potential therapeutic target in fibromyalgia: A hypothesis

Figure 2 Pathophysiology of fibromyalgia. Neuronal excitability due to amplified and altered central nervous system functioning linked to peripheral generators is associated with central sensitization. The central sensitization reflects the altered biochemistry and neurotransmitter levels. Up arrow: Raised levels relative to healthy subjects; Down arrow: Lowered levels relative to healthy subjects; CFS: Cerebrospinal fluid.