Copyright
©The Author(s) 2016.
Figure 1 The hypothesis: In the whole animal, epileptic seizures provide the repetitive stimulation required for the expression of ganglionic long-term potentiation in sympathetic ganglia, resulting in increased peripheral resistance, hypertension and cardiopulmonary dysregulation leading to sudden death.
Blocking serotonin 5-HT3 receptor with antagonist (Zofran©) in ganglia has been shown to obviate the effect of gLTP. gLTP: Ganglionic long-term potentiation; CNS: Central nervous system; SUDEP: Sudden unexpected death in epilepsy.
- Citation: Alkadhi KA. Long-term potentiation in autonomic ganglia: Potential role in cardiovascular disorders. World J Pharmacol 2016; 5(2): 51-58
- URL: https://www.wjgnet.com/2220-3192/full/v5/i2/51.htm
- DOI: https://dx.doi.org/10.5497/wjp.v5.i2.51