Alpha-glutamyl-tryptophan as adjuvant reparative therapy after Helicobacter pylori eradication in chronic atrophic gastritis: A case report and literature review

Table 1 Dynamics of laboratory and instrumental findings before and after eradication therapy and adjuvant repair therapy with alpha-glutamyl-tryptophan

Parameter	Before treatment	After treatment	Normal values
Endoscopic findings
Hyperemia of gastric mucosa, points	3	1	0
Edema of gastric mucosa, points	2	1	0
Kimura–Takemoto classification	C1	C1	0
Test for verification of H. pylori infection (rapid urease test)	+	-	-
Histological findings
Number of glands per 1 mm² of the gastric mucosa	14	21	NA1 (↑)2
Gland depth of gastric mucosa, µm	155.9	192.6	NA1 (↑)2
H. pylori staining	+	-	-
Number of parietal cells per 100 epithelial cells	0	16	NA1 (+)3
Number of goblet cells per 100 epithelial cells	3	0	0
OLGA/OLGIM stage	II/I	I/0	0/0
Immunohistochemical findings
CDX-2 relative expression area (%)	12.1	7	0
CXCL-12 relative expression area (%)	17	7.94	NA1 (↓)4
GastroPanel findings
Pepsinogen I (μg/L)	41	155	30–160
Pepsinogen II (μg/L)	26	8.1	3–15
Pepsinogen I/II ratio	1.6	19.1	> 3
Gastrin-17 (pmol/L)	41	1.7	1–10
Anti-H. pylori IgG (U/mL)	43	19	< 30
24-h pH monitoring findings
Mean pH value	6.8	1.2	1.0–3.0

¹NA: No standardized reference values available.

²(↑) An increase in the parameter was considered a positive trend.

³(+) Appearance of the parameter was considered a positive trend.

⁴(↓) A decrease in the parameter was considered a positive trend.

H. pylori: Helicobacter pylori; NA: Not available; OLGA: Operative Link for Gastritis Assessment; OLGIM: Operative Link for Gastric Intestinal Metaplasia Assessment.