Mazdutide: An emerging glucagon/GCG-like peptide-1 dual receptor agonist for obesity—a comparison of therapeutic effects and potential side effects with GCG-like peptide-1 inhibitors

Figure 5 Mechanistic pathways of mazdutide via dual glucagon-like peptide-1 receptor and glucagon receptor activation. Mazdutide plays an important role in the digestive system (stomach, pancreas, and liver), cardiovascular system, and central nervous system (brain), and it regulates weight, metabolism, blood glucose, and cardiovascular risk factors. TG: Triglycerides; GLP-1R: Glucagon-like peptide-1 receptor; GLP-1: Glucagon-like peptide-1; GCGR: Glucagon receptor; LDL-C: Low-density lipoprotein cholesterol; GLU: Glutamate; NTS: Nucleus of the solitary tract; RVLM: Rostral ventrolateral medulla.