Commentary: Discussing the antidepressant potential of silymarin

Figure 1 Effects of silymarin alone on the pathogenesis and symptoms of depression in a study on dexamethasone-induced mice. ¹Indicates significant difference in the group administered silymarin 280 mg/kg only. ²Indicates significant difference in both silymarin 140 mg/kg and 280 mg/kg. ³Activity includes tail suspension and forced swim tests, elevated plus maze, and locomotor activity. ↑ Indicates a significant increase (P < 0.05) relative to dexamethasone-induced mice. ↓ Indicates a significant decrease (P < 0.05) relative to dexamethasone-induced mice. GPx: Glutathione peroxidase; GSH: Glutathione; IL-10: Interleukin-10; MDA: Malondialdehyde; SOD: Superoxide dismutase; TNF- α: Tumor necrosis factor-alpha.