Earlier onset and multiple primaries in familial as opposed to sporadic esophageal cancer

Table 3 Significant and independent predictors of familial esophageal squamous cell cancer by multivariate logistic analysis

Variables entered at each step	Regression coefficient	Standard error	Wald test value	P-value	OR	95%CI
						Lower	Upper
Step 1
Sex	-0.057	0.146	0.153	0.696	0.944	0.709	1.258
Age	-0.026	0.006	21.06	0.000b	0.975	0.964	0.985
Primary tumor site	0.235	0.349	0.451	0.502	0.791	0.399	1.568
Tobacco	0.153	0.140	1.195	0.274	1.165	0.886	1.532
Alcohol	0.113	0.112	1.019	0.313	1.120	0.899	1.396
Multiple cancer	1.427	0.267	28.49	0.000b	4.166	2.467	7.036
Presurgical radiotherapy	0.161	0.179	0.813	0.367	1.175	0.828	1.669
Constant	0.592	0.827	0.512	0.474	1.808
Step 2
Age	-0.026	0.006	21.068	0.000b	0.975	0.964	0.985
Primary tumor site	-0.241	0.349	0.479	0.489	0.786	0.397	1.556
Tobacco	0.187	0.108	3.001	0.083	1.206	0.967	1.491
Alcohol	0.123	0.110	1.250	0.264	1.131	0.912	1.402
Multiple cancer	1.427	0.267	28.497	0.000b	4.166	2.467	7.035
Presurgical radiotherapy	0.160	0.179	0.802	0.371	1.174	0.827	1.667
Constant	0.462	0.758	0.372	0.542	1.588
Step 3
Age	-0.026	0.006	21.311	0.000b	0.974	0.964	0.985
Tobacco	0.185	0.108	2.926	0.087	1.203	0.973	1.487
Alcohol	0.122	0.110	1.236	0.266	1.130	0.911	1.401
Multiple cancer	1.446	0.266	29.56	0.000b	4.246	2.521	7.152
Presurgical radiotherapy	0.157	0.179	0.773	0.379	1.170	0.824	1.662
Constant	-0.004	0.346	0.000	0.990	0.996
Step 4
Age	-0.026	0.006	22.395	0.000b	0.974	0.963	0.985
Tobacco	1.187	0.108	3.000	0.083	1.206	0.976	1.491
Alcohol	0.117	0.110	1.146	0.284	1.125	0.907	1.394
Multiple cancer	1.438	0.266	29.282	0.000b	4.213	2.502	7.092
Constant	0.037	0.343	0.011	0.915	1.037
Step 5
Age	-0.026	0.006	22.364	0.000b	0.974	0.963	0.985
Tobacco	0.240	0.096	6.245	0.012a	1.271	1.053	1.535
Multiple cancer	1.451	0.265	29.862	0.000b	4.265	2.535	7.176
Constant	0.108	0.337	0.104	0.747	1.114

^aP < 0.05,

^bP < 0.01 vs standard error.