Earlier onset and multiple primaries in familial as opposed to sporadic esophageal cancer

doi:10.5496/wjmg.v4.i2.39

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World Journal of Medical Genetics

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2220-3184

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Med Genet. May 27, 2014; 4(2): 39-45
Published online May 27, 2014. doi: 10.5496/wjmg.v4.i2.39

Table 1 Difference in age at onset in patients with esophageal squamous cell carcinomas with and without a family history of the cancer

	Positive family history		Negative family history		Differences	Pt-test
	n (%)	Mean age (yr) ± SD (1)	n (%)	Mean age (yr) ± SD (2)	(1)-(2)	(1)-(2)
Total	766	51.83 ± 8.39	1776	53.49 ± 8.23	-1.66	0.000^b
Sex
Female	229 (33.80)	52.46 ± 7.91	600 (29.90)	53.48 ± 7.81	-1.02	0.100
Male	537 (66.20)	51.56 ± 8.58	1176 (70.10)	53.49 ± 8.44	-1.93	0.000^b
Tobacco
Nonsmoker	282 (36.80)	52.66 ± 8.03	739 (41.60)	53.63 ± 8.27	-0.98	0.090
Smoker	484 (63.20)	51.35 ± 8.56	1037 (58.40)	53.38 ± 8.13	-2.03	0.000^b
Alcohol
Nondrinker	480 (62.70)	52.10 ± 8.37	1200 (67.60)	53.38 ± 8.21	-1.29	0.004^a
Drinker	286 (37.30)	51.38 ± 8.42	578 (32.40)	53.70 ± 8.28	-2.32	0.000^b
Surgery year
1975-1979	224 (29.20)	50.90 ± 8.21	376 (21.20)	52.36 ± 8.00	-1.46	0.034^a
1980-1984	216 (28.20)	51.69 ± 8.58	545 (30.70)	52.95 ± 8.18	-1.26	0.050^a
1985-1989	326 (42.60)	52.56 ± 8.34	855 (48.10)	54.32 ± 8.28	-1.76	0.001^b
TNM
T_is,1N₀M₀	34 (4.40)	50.94 ± 9.78	66 (3.70)	55.52 ± 7.24	-4.57	0.010^a
T_2,3N₀M₀	422 (55.10)	51.64 ± 8.30	983 (55.30)	53.30 ± 8.37	-1.67	0.001^b
T_2,3,4N₁M₀	310 (40.50)	52.19 ± 8.37	727 (40.90)	53.55 ± 8.10	-1.36	0.010^a
Resection
Exploratory	16 (2.10)	49.88 ± 8.16	28 (1.60)	52.57 ± 9.18	-2.70	0.340
R1 or R2	70 (9.10)	49.33 ± 10.00	152 (8.60)	54.73 ± 8.49	-5.40	0.000^b
R0	680 (88.80)	52.13 ± 8.17	1596 (89.90)	53.38 ± 8.18	-1.25	0.001^b

Positive family history vs negative family history,

^aP < 0.05,

^bP < 0.01.

Citation: Wen XD, Wen DG, Yang Y, Shan BE, Wang SJ. Earlier onset and multiple primaries in familial as opposed to sporadic esophageal cancer. World J Med Genet 2014; 4(2): 39-45
URL: https://www.wjgnet.com/2220-3184/full/v4/i2/39.htm
DOI: https://dx.doi.org/10.5496/wjmg.v4.i2.39