Mineralocorticoid receptor genetics: A scoping review

doi:10.5496/wjmg.115237

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World Journal of Medical Genetics

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2220-3184

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Med Genet. Sep 30, 2026; 14(1): 115237
Published online Sep 30, 2026. doi: 10.5496/wjmg.115237

Table 6 Adipose and ocular expression of mineralocorticoid receptor

Organ	Specie	Cellular location	Functional role
Adipose tissues[52-54]	Mouse	White adipocytes	Proadipogenic, promoting the differentiation of preadipocytes into mature fat cells
Adipose tissues[55-57]	Mouse	Brown adipocytes	Promotes differentiation and down-regulates UCP1 and UCP3 expression, contributing to the regulation of cellular energy expenditure
Retina[58-60]	Rat	Müller glial cells	Regulates Na⁺, K⁺ and water channel expression (ENaC-α, Kir4.1, AQP4)
Retina[58-60]	Rat/human	Choroid (vascular endothelium)	Choroidal vascular permeability and vasodilation by KCa23 channel regulation
Iris-ciliary body[61]	Rabbit	ND	ND

AQP: Aquaporin; ENaC: Epithelial sodium channel; Kir: Inwardly rectifying potassium channel; ND: Not described; UCP: Uncoupling protein.

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Citation: Jaurretche SPA, Balañá C, Bascolo RM. Mineralocorticoid receptor genetics: A scoping review. World J Med Genet 2026; 14(1): 115237
URL: https://www.wjgnet.com/2220-3184/full/v14/i1/115237.htm
DOI: https://dx.doi.org/10.5496/wjmg.115237

Jaurretche SPA, Balañá C, Bascolo RM. Mineralocorticoid receptor genetics: A scoping review. World J Med Genet 2026; 14(1): 115237 [DOI: 10.5496/wjmg.115237]

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