Mineralocorticoid receptor genetics: A scoping review

doi:10.5496/wjmg.115237

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World Journal of Medical Genetics

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2220-3184

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Med Genet. Sep 30, 2026; 14(1): 115237
Published online Sep 30, 2026. doi: 10.5496/wjmg.115237

Table 5 Heart and cardiovascular system expression of mineralocorticoid receptor

Organ	Specie	Cellular location	Functional role
Heart[43-45]	Rat	Myocytes	Induces cardiomyocyte hypertrophy
Heart[46-48]	Mouse	Myocytes	Ventricular contractile dysfunction
			Increases ROS at and mitochondrial myocardial level, through the overexpression of NADPH oxidase
			Cardiac fibrosis and remodeling
			Apoptosis
Heart, blood vessels[49,50]	Rabbit	Myocytes; endothelial and vascular smooth muscle cells	Promotes endothelial dysfunction and oxidative stress in atherosclerosis
Heart, blood vessels[51]	Rat	Myocytes; endothelial and vascular smooth muscle cells	Promotes vascular smooth muscle cells proliferation

ROS: Reactive oxygen species.

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Citation: Jaurretche SPA, Balañá C, Bascolo RM. Mineralocorticoid receptor genetics: A scoping review. World J Med Genet 2026; 14(1): 115237
URL: https://www.wjgnet.com/2220-3184/full/v14/i1/115237.htm
DOI: https://dx.doi.org/10.5496/wjmg.115237

Jaurretche SPA, Balañá C, Bascolo RM. Mineralocorticoid receptor genetics: A scoping review. World J Med Genet 2026; 14(1): 115237 [DOI: 10.5496/wjmg.115237]

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