Mineralocorticoid receptor genetics: A scoping review

doi:10.5496/wjmg.115237

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World Journal of Medical Genetics

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2220-3184

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Med Genet. Sep 30, 2026; 14(1): 115237
Published online Sep 30, 2026. doi: 10.5496/wjmg.115237

Table 4 Central nervous system expression of mineralocorticoid receptor

Organ	Specie	Cellular location	Functional role
CNS[34-37]	Rat	Hippocampus: Pyramidal neurons of CA1-CA4; granule cells of dentate gyrus	Increases neuronal excitability, facilitating action potential firing
CNS[38]	Mouse	Hippocampus: Pyramidal neurons of CA1-CA4; granule cells of dentate gyrus	Increases glutamate release, strengthening synaptic communication
CNS[39,40]	Mouse	Hippocampus: Pyramidal neurons of CA1-CA4; granule cells of dentate gyrus	Lower anxiety and regulation of the stress response
CNS[39,40]	Mouse		Long-term survival and maintenance of mature granule neurons
CNS[41,42]	Rat	Hippocampus: Pyramidal neurons of CA1-CA4; granule cells of dentate gyrus	Inhibition progenitor proliferation
CNS[41,42]	Rat		Synaptic plasticity: Hippocampal long-term potentiation, memory formation, particularly under stress conditions
CNS[34-36]	Rat	Hypothalamus: Parvocellular and magnocellular neurons of PVN and ARC	ND

ARC: Arcuate nucleus; CA: Cornu ammonis; CNS: Central nervous system; ND: Not described; PVN: Paraventricular nucleus.

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Citation: Jaurretche SPA, Balañá C, Bascolo RM. Mineralocorticoid receptor genetics: A scoping review. World J Med Genet 2026; 14(1): 115237
URL: https://www.wjgnet.com/2220-3184/full/v14/i1/115237.htm
DOI: https://dx.doi.org/10.5496/wjmg.115237

Jaurretche SPA, Balañá C, Bascolo RM. Mineralocorticoid receptor genetics: A scoping review. World J Med Genet 2026; 14(1): 115237 [DOI: 10.5496/wjmg.115237]

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