Mineralocorticoid receptor genetics: A scoping review

Table 3 Ear and blood expression of mineralocorticoid receptor

Organ	Specie	Cellular location	Functional role
Inner ear[26]	Rat	Marginal cells of the stria vascularis and spiral ganglion neurons	Regulates endolymph homeostasis by controlling Na+/K+-ATPase activity
Inner ear[27,28]	Guinea pig	Lateral wall of the cochlea basal turn and the ampullae of the semicircular canals	ND
Inner ear[29]	Mouse	Ampulla epithelial cells of semicircular canal	Expressed functional MR and 11β-HSD2; promoted Na+ absorption and K+ secretion through the IsK/KvLQT1 channel
Blood[30-33]	Human	Mononuclear leukocytes	Intracellular Na+/K+ balance
			Induces oxidative stress (↑ p22phox); and upregulates PAI-1 expression
			Induces trained immunity

ND: Not described; MR: Mineralocorticoid receptor; PAI-1: Plasminogen activator inhibitor-1.