Mineralocorticoid receptor genetics: A scoping review

doi:10.5496/wjmg.115237

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World Journal of Medical Genetics

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2220-3184

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Med Genet. Sep 30, 2026; 14(1): 115237
Published online Sep 30, 2026. doi: 10.5496/wjmg.115237

Table 2 Epithelial expression of mineralocorticoid receptor

Organ	Specie	Cellular location	Functional role
Colon[17-19]	Rat, human, chicken	Enterocyte	Transepithelial Na⁺ and water transport
Airway[20]	Rat	Trachea to bronchioles	ND
Salivary glands[21]	Rat	Parotid	ND
Sweat glands[22]	Human	Duct epithelial cells	Na⁺ and K⁺ sweat composition and prevents excessive salt loss during heat acclimatization
Skin[22]	Human	Keratinocytes, hair follicle	ND
Skin[23]	Mouse	Keratinocytes	Restrains keratinocyte proliferation and fine-tunes differentiation to maintain epidermal balance
Skin[24]	Mouse	Keratinocytes	Keratinocyte-specific anti-inflammatory action, by inhibiting NF-κB and STAT3 pathways
Skin[25]	Mouse	Keratinocytes	Normal keratinocyte motility and dermal remodeling during wound repair

ND: Not described.

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Citation: Jaurretche SPA, Balañá C, Bascolo RM. Mineralocorticoid receptor genetics: A scoping review. World J Med Genet 2026; 14(1): 115237
URL: https://www.wjgnet.com/2220-3184/full/v14/i1/115237.htm
DOI: https://dx.doi.org/10.5496/wjmg.115237

Jaurretche SPA, Balañá C, Bascolo RM. Mineralocorticoid receptor genetics: A scoping review. World J Med Genet 2026; 14(1): 115237 [DOI: 10.5496/wjmg.115237]

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