Circular RNA: The evolving potential in the disease world

Table 1 Circular RNAs as potential biomarkers in major human diseases

Body system	Disease	circRNA	Expression	Ref.
Cardiovascular	Myocardial infarction	circRNA_081881	Down	[43]
		MICRA	Up
	Cardiac fibrosis	circRNA_010567	Up	[44]
	Congenital heart disease	hsa_circ_004183	Down	[45]
		hsa_circ_079265
		hsa_circ_105039
	Hypertension	hsa_circ_0037911	Up	[46]
	Cardiomyopathy	circDNAJC6	Down	[47]
		circTMEM56
		circMBOAT2
	Heart failure	hsa_circ_0062960	Up	[48]
	Coronary artery disease	hsa_circ_0124644	Down	[49]
		hsa_circ_0001879	Down	[50]
		hsa_circ_0004104	Down	[51]
		hsa_circ_0001445	Up
	Atrial fibrillation	hsa_circ_025016	Up	[52]
Central nervous system	Moyamoya disease	hsa_circRNA_089761	Down	[53]
		hsa_circRNA_100914
		hsa_circRNA_089763
	Temporal lobe epilepsy	circ-EFCAB2	Up	[54]
		circ-DROSHA	Down	[55]
		circRNA-0067835	Down
	Alzheimer’s disease	CDR1as/ciRS-7	Down	[56,57]
		circPVT1	Up	[58]
	Parkinson’s disease	CDR1as/ciRS-7	Up	[59]
		circzip-2
	Multiple sclerosis	circ_0005402	Down	[60]
		circ_0035560		[61]
	Prion disease	CDR1as/ciR-7	Up	[56,62]
Psychiatry	Schizophrenia	hsa_circRNA_104597	Down	[63]
Respiratory	Tuberculosis	hsa_circRNA_001937	Up	[64]
		hsa_circRNA_005086	Up	[35]
		hsa_circRNA_009024	Up
		hsa_circRNA_104964	Down
		hsa_circRNA_102101	Down
		hsa_circRNA_104296	Down
	Siliocosis	hsa_circ_0058493	Up	[65]
		circRNA-012091	Down	[66]
	Pulmonary hypertension	circ-GSAP	Down	[67]
		circ_0068481	Up	[68]
	Acute respiratory distress syndrome	hsa_circRNA_101952	Up	[69]
		hsa_circRNA_101523	Up
		hsa_circRNA_102927	Down
		hsa_circRNA_100562	Down
		hsa_circRNA_102034	Down
Endocrine	Diabetes mellitus	CiRS-7	Up	[70]
		hsa_circ_0068087		[71]
		hsa_circ_0124636		[71]
		hsa_circ_0139110
		hsa_circ_0054633
	Diabetes/glucose	CDR1as/cirRS-7	Up	[70,72]
	Homeostasis/CVD	circRNA-HIPK3	Up	[73]
		circRNA-WDR77	Up
		circANKRD36	Up
	Diabetic cardiomyopathy	circRNA_000203	Up	[74]
		circRNA_010567	Up	[44]
		hsa-circ-0076631	Up	[75]
	Diabetic nephropathy	circRNA_15698	Up	[59,75,76]
	Gestational diabetes	circ_5824	Down	[75]
		circ_3636	Down
		circ_0395	Down
	Diabetic retinopathy	circRNA-0005015	Up	[75]
		circRNA-HIPK3	Up	[77]
		cZNF609	Up	[78]
		circRNA-cPWWP2A	Up	[79]