ARB affects nicotine-induced gene expression profile in human coronary artery endothelial cells

Figure 1 Gene network in human coronary artery endothelial cell cultured with 100 μmol/L nicotine for 24 h was generated by ingenuity pathway analysis software. We focused on one network whose function was implicated in “tissue development, cardiovascular system development and function, cell-to-cell signaling and interaction”. Genes are represented as nodes and the biological relationship between two nodes is represented as a line. Solid lines are for direct and broken ones for indirect associations. Lines beginning and ending at a single node show self-regulation, whereas a line without an arrowhead represents binding. Arrowheads represent directionality of the relationship. The node color intensity indicates the degree of increase (red) or decrease (green). ADAM: A disintegrin and metalloprotease domain; MMP: Matrix metalloproteinase.