Induction of tissue angiotensin II-forming activity in two-kidney, one-clip hypertensive hamster model

Figure 3 Cardiac tissue angiotensin II-forming activity in two-kidney, one-clip hypertensive hamsters. Cardiac tissue (A) total, (B) chymase-, (C) angiotensin converting enzyme (ACE)-, and (D) other enzyme-dependent Ang II-forming activities in sham-operated and two-kidney, one-clip (2K1C) hypertensive hamsters. Hamster hearts were removed, and activities were measured at 18 wk after clipping either without or with ACE inhibitor (ACE-I) (Temocapril; 30 mg/kg per day) or angiotensin II type 1 receptor antagonist (ARB) (CS866; 10 mg/kg per day) treatment. Results are presented as means ± SEMs; n = 6 per group. ^bP < 0.01, ^aP < 0.05, ^cP < 0.1 vs Vehicle; ^dP < 0.01 vs Sham.