Statin escape phenomenon: Fact or fiction?

doi:10.5493/wjem.v7.i1.25

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World Journal of Experimental Medicine

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2220-315x

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

World J Exp Med. Feb 20, 2017; 7(1): 25-30
Published online Feb 20, 2017. doi: 10.5493/wjem.v7.i1.25

Table 2 Lipid and metabolic profile of study participants

	Baseline visit	Visit at 6 mo	Most recent visit
TCHOL, mg/dL
Escape group	258 (233-283)	162 (147-174)	182 (170-201)
Non-escape group	259 (235-295)	184 (162-206)^a	172 (154-193)^a
TG, mg/dL
Escape group	117 (89-175)	97 (69-117)	104 (87-129)
Non-escape group	132 (99-181)	104 (83-140)^a	108 (79-130)
HDL-C, mg/dL
Escape group	53 (47-68)	55 (43-64)	54 (48-68)
Non-escape group	53 (46-65)	52 (44-60)	56 (46-62)
LDL-C, mg/dL
Escape group	174 (152-189)	88 (78-97)	103 (96-118)
Non-escape group	177 (152-205)	109 (91-129)^a	94 (79-114)^a
Non-HDL, mg/dL¹
Escape group	204 (181-223)	107 (97-121)	127 (116-143)
Non-escape group	209 (182-241)	132 (115-153)^a	118 (102-137)^a
BMI, kg/m²
Escape group	27.3 (23.5-29.9)	27.2 (23.5-30.1)	27.6 (24-30.2)
Non-escape group	27.9 (25.5-30.6)	28.3 (25.1-30.9)	28.4 (25.5-31.5)
Fasting glucose, mg/dL
Escape group	95 (88-105)	95 (87-129)	95 (88-106)
Non-escape group	93 (87-103)	94 (88-104)	96 (89-106)
HbA1c, %²
Escape group	8.5 (6.7-8.6)	6.6 (5.6-5.9)	6.7 (6.6-7.1)
Non-escape group	8.4 (7.7-10.9)	6.7 (6.3-7.9)	6.9 (6.3-7.6)
MDRD-eGFR, mL/min per 1.73 m²
Escape group	77 (69.6-86.7)	76.6 (67.9-84.8)	76.5 (65.4-81)
Non-escape group	81 (70.7-91.4)	79.7 (69-89.7)	76.9 (65.5-85.7)

Values are expressed as median (IQR). To convert from mg/dL to mmol/L multiply by 0.0555 for glucose, 0.02586 for TC, HDL-C, LDL-C, and 0.01129 for TG.

¹Non-HDL-C levels refer to non-diabetic individuals (n = 164);

²HbA1c values refer to diabetic individuals (n = 17).

^aP < 0.05 for the comparison with the escape group. BMI: Body mass index; MDRD-eGFR: Estimated glomerular filtration rate according to The Modification of Diet in Renal Disease (MDRD) Study equation; HbA1c: Glycated hemoglobin; HDL-C: High-density lipoprotein cholesterol; IQR: Interquartile range; LDL-C: Low-density lipoprotein cholesterol; non-HDL-C: Non-high-density lipoprotein cholesterol; TCHOL: Total cholesterol; TG: Triglycerides.

Citation: Barkas F, Elisaf M, Klouras E, Dimitriou T, Tentolouris N, Liberopoulos E. Statin escape phenomenon: Fact or fiction? World J Exp Med 2017; 7(1): 25-30
URL: https://www.wjgnet.com/2220-315X/full/v7/i1/25.htm
DOI: https://dx.doi.org/10.5493/wjem.v7.i1.25