Clinical significance of differential plasma proteins levels in the diagnosis of epithelial ovarian cancer

doi:10.5493/wjem.v15.i3.107711

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World Journal of Experimental Medicine

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Exp Med. Sep 20, 2025; 15(3): 107711
Published online Sep 20, 2025. doi: 10.5493/wjem.v15.i3.107711

Table 5 Correlation among the tested variables in epithelial ovarian cancer patients

		HE4	IGFBP2	TSP1	SPP1	CA19-9	CA15-3	D-dimer
CA125	r value	0.365	0.131	0.001	0.183	-0.071	-0.446	0.046
CA125	P value	0.004	0.318	0.995	0.161	0.879	0.268	0.791
HE4	r value		-0.018	0.101	0.255	-0.536	0.759	0.220
HE4	P value		0.891	0.444	0.050	0.215	0.029	0.204
IGFBP2	r value			0.306	0.031	-0.643	0.470	0.376
IGFBP2	P value			0.018	0.815	0.119	0.240	0.026
TSP1	r value				-0.058	-0.643	0.349	-0.298
TSP1	P value				0.707	0.119	0.396	0.082
SPP1	r value					0.107	0.325	-0.009
SPP1	P value					0.819	0.432	0.959

r: Spearman's rho. CA: Cancer antigen; HE4: Human epididymis protein 4; IGFBP2: Insulin-like growth factors-binding proteins 2; SPP1: Secreted phosphoprotein 1; TSP1: Thrombospondin 1 protein.

Citation: Ibrahim NH, Abdellateif MS, Serag DS, Laymouna A, Elaguizy MS, Halim RMA. Clinical significance of differential plasma proteins levels in the diagnosis of epithelial ovarian cancer. World J Exp Med 2025; 15(3): 107711
URL: https://www.wjgnet.com/2220-315X/full/v15/i3/107711.htm
DOI: https://dx.doi.org/10.5493/wjem.v15.i3.107711