Clinical significance of differential plasma proteins levels in the diagnosis of epithelial ovarian cancer

Table 3 Diagnostic accuracy of the assessed markers for the epithelial ovarian cancer patients

Test variables	Area under the receiver operating characteristic curve	Cutoff value	Sensitivity	Specificity	P value
CA125	0.943	41.1	90%	100%	< 0.001
HE4	0.936	66.4	82%	93.3%	< 0.001
Insulin-like growth factors-binding proteins 2	0.981	553.1	98%	100%	< 0.001
TSP1	0.653	2460	70%	66.7%	0.046
SPP1	0.908	8.64	86.7%	100%	< 0.001
TSP1 + SPP1	0.968	-	93.3%	100%	< 0.001
CA125 + SPP1	0.968	-	93.3%	100%	< 0.001
CA125 + HE4	0.962	-	91.7%	93.3%	< 0.001
CA125 + TSP1	0.949	-	95%	83.3%	< 0.001

CA125: Cancer antigen 125; HE4: Human epididymis protein 4; SPP1: Secreted phosphoprotein 1; TSP1: Thrombospondin 1 protein.