Clinical significance of differential plasma proteins levels in the diagnosis of epithelial ovarian cancer

doi:10.5493/wjem.v15.i3.107711

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World Journal of Experimental Medicine

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Exp Med. Sep 20, 2025; 15(3): 107711
Published online Sep 20, 2025. doi: 10.5493/wjem.v15.i3.107711

Table 2 Plasma protein levels in different study groups

	Control (n = 30)	Benign (n = 10)	Malignant (n = 50)	P value
Cancer antigen 125 (U/mL)	12.2 (3.1-25.9)^a	28.6 (3.5-1217)^b	232 (5.5-3649)^c	< 0.001
Human epididymis protein 4 (pmol/L)	41.6 (3.8-83.8)^a	93.4 (37-800)^b	283 (37-5908)^b	< 0.001
Insulin-like growth factors-binding proteins 2 (pg/mL)	273 (117-353)^a	2641 (1114-3773)^b	2669 (146-5785)^b	< 0.001
Thrombospondin 1 protein (pg/mL)	2899 (95-8500)	1702 (560-3540)	1803 (92-8500)	0.051
Secreted phosphoprotein 1 (ng/mL)	4.2 (1.9-6.3)^a	3.98 (0.85-11.5)^a	40.4 (11-76.5)^b	< 0.001
D-dimer (ng/mL)	0.1 (0-0.5)^a	832 (262-3429)^b	744 (50-1000)^b	< 0.001

^aP < 0.05.

^bP < 0.01.

^cP < 0.001.

Analysis was done using Kruskal-Walli’s test with post hoc pairwise Mann Whiteny test.

Citation: Ibrahim NH, Abdellateif MS, Serag DS, Laymouna A, Elaguizy MS, Halim RMA. Clinical significance of differential plasma proteins levels in the diagnosis of epithelial ovarian cancer. World J Exp Med 2025; 15(3): 107711
URL: https://www.wjgnet.com/2220-315X/full/v15/i3/107711.htm
DOI: https://dx.doi.org/10.5493/wjem.v15.i3.107711