Gas chromatography-mass spectrometry-based plasma metabolomics analysis in hypertensive patients with Yin deficiency and Yang hyperactivity syndrome

Table 2 Differential metabolites between the two groups

No.	Var ID	HMDB	KEGG	FC	P value	PubChem	Trend
1	4-Hydroxybenzoic acid	HMDB0000500	C00156	11.566	< 0.01	135	↑
2	Pectin	HMDB0003402	C08348	3.1576	< 0.01	65550	↑
3	1,2,3-Trihydroxybenzene	HMDB0013674	C01108	2.7443	0.033	3446	↑
4	D-Ribose	HMDB0000283	C00121	2.6621	< 0.01	5779	↑
5	3-Hydroxybutyric acid	HMDB0000357	C01089	2.2031	0.011	441	↑
6	Quinic acid	HMDB0003072	C00296	1.8801	0.034	6508	↑
7	L-Lysine	HMDB0000182	C00047	1.6739	< 0.01	6508	↑
8	Oleic acid	HMDB0000207	C00712	1.5228	≤ 0.01	445639	↑
9	2-Hydroxybutyric acid	HMDB0000008	C05984	1.4935	0.01	11266	↑
10	Linoleic acid	HMDB0000673	159	14928	0.040	5280450	↑
11	Citric acid	HMDB0000094	C00158	1.4718	0.01	311	↑
12	Alpha-tocopherol	NA	NA	1.375	0.01	NA	↑
13	D-Glucuronic acid	HMDB0000127	C00191	1.3608	< 0.01	94715	↑
14	Glycerol	HMDB0000131	C00116	1.3121	< 0.01	753	↑
15	N-Acetyl-L-aspartic acid	HMDB0000812	C01042	0.48705	0.01	65065	↓
16	Beta-mannosylglycerate	NA	NA	0.59765	< 0.01	NA	↓
17	Indolelactic acid	HMDB0000671	C02043	0.65739	0.011	92904	↓
18	L-Glutamic acid	HMDB0000148	C00025	0.66721	0.011	33032	↓
19	D-Maltose	HMDB0000163	C00208	0.69193	0.01	10991489	↓
20	L-Aspartic acid	HMDB0000191	C00049	0.70828	0.042	5960	↓

According to substance comparison, numbers 2, 3, 4, 5, 7, 13, 17, 18, 19, and 20 correspond to lyxose, pyrogallol, ribose, betahydroxybutyric acid, lysine, glucuronic acid, indole-3 act, glutamic acid, maltose 1, and aspartate, respectively. FC: Fold change.