Review
Copyright ©2014 Baishideng Publishing Group Co.
World J Crit Care Med. Feb 4, 2014; 3(1): 15-23
Published online Feb 4, 2014. doi: 10.5492/wjccm.v3.i1.15
Table 4 Management of biologic agents
AgentPediatric dosingNotes
Inhalational anthraxCiprofloxacin 10-15 mg/kg iv q 12 h (max 400 mg) or doxycycline 2.2 mg/kg iv q 12 h (max 100 mg) plus clindamycin 10-15 mg/kg q 8 plus penicillin G 400-600 k U/kg per day iv divided q 4 h prophylaxis for exposed contacts ciprofloxacin 15 mg/kg po q 12 h or doxycycline 2.2 mg/kg po q 12 hSwitch to oral therapy when patient shows signs of improvement At least one agent should have good CNS penetration Prophylaxis is for a 60 d course Amoxicillin or levofloxacin are second line
PlagueGentamycin 2.5 mg/kg iv q 8 h or streptomycin 15 mg/kg im q 12 h (max 2 mg/d) or doxycycline 2.2 mg/kg iv q 12 h (max 200 mg/d) or ciprofloxacin 15 mg/kg iv q 12 h prophylaxis for exposed contacts trimethoprim/sulfa 4 mg/kg po q 12 hChloramphenical or Levofloxacin can also be used Prophylaxis should be continued for 5-7 d
TularemiaSame as therapy for plague
BotulismInfants < 1 yr human-derived botulinum immunoglobulin children > 1 yr equine serum botulism antitoxinIn United States call 1-800-222-1222 or 770-488-7100 Outside United States contact local health agencies