Characterizing the molecular landscape of venous congestion

Figure 2 Top circulating markers in studies with measures of venous congestion. Circulating markers reported by > 3% of studies (5 or more studies) are shown. Cardiovascular and endothelial signaling proteins were the most frequently reported proteins. The bar graph demonstrates the number of studies (Y-axis) that reported clinical associations or findings with the identified proteins (X-axis). The proportion (%) of the 145 studies that report each protein is included above the green bars. The pie charts represent the disease states in which the proteins were quantified (cardiac: Dark blue; pulmonary: Light blue; renal: Beige; hepatic/abdominal: White; peripheral congestion: Grey). A complete list of all reported circulating markers with associations with results or outcomes in studies with measures of venous congestion is shown in Supplementary Table 2. BNP: B-type natriuretic peptide; ET-1: Endothelin 1; VEGF: Vascular endothelial growth factor; CRP: C-reactive protein; IL-6: Interleukin-6; TNF: Tumor necrosis factor; FGF: Fibroblast growth factor.