Characterizing the molecular landscape of venous congestion

Table 1 Characteristics of included studies, n (%)/median (interquartile range)

Variable	All studies	Critical care studies
Total manuscripts	145 (100)	5 (100)
Type of study
Prospective	88 (60.7)	2 (40.0)
Retrospective	46 (31.7)	0 (0)
Cross sectional	5 (3.4)	1 (20.0)
Case control	2 (1.4)	1 (20.0)
Other/mixed	5 (3.4)	1 (20.0)
Setting
Inpatient not specified	57 (39.3)
Outpatient	36 (24.8)
Mixed inpatient/outpatient	17 (11.7)
Cardiac unit	10 (6.9)
Emergency department	8 (5.5)
Other/not specified	8 (5.5)
Intensive care	5 (3.4)	5 (100)
Medicine unit	3 (2.1)
Operating room/surgical	1 (0.7)
Sample size
Overall	164.0 (83.5-442.0)	91.0 (70.5-255.0)
< 100 subjects	44 (30.3)	3 (60.0)
100-1000 subjects	79 (54.5)	2 (40.0)
> 1000 subjects	22 (15.2)	0 (0)
Dedicated biomarker study	43 (29.7)	2 (40.0)
Validation cohort used	10 (6.9)	1 (20.0)
Number of proteins quantified
Overall	2 (1.0-3.0)	1 (1.0-2.0)
1	68 (46.9)	4
2-10	68 (46.9)	1
11-100	7 (4.8)	0
> 100	2 (1.4)	0
Method of protein quantification
Immunoassays	74 (51.0)	3 (60.0)
O-link proximity extension	6 (4.1)	0 (0)
Not specified	65 (44.8)	2 (40.0)
Frequency of sampling
Single time point	68 (46.9)	2 (40.0)
Longitudinal	57 (39.3)	3 (60.0)
Not specified	20 (13.7)	-
Study outcome measured congestion	37 (25.5)	3