Methylene blue for treating toxic encephalopathy due to acute nickel poisoning: A case report

doi:10.5492/wjccm.120702

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World Journal of Critical Care Medicine

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2220-3141

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Case Report

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Crit Care Med. Sep 9, 2026; 15(3): 120702
Published online Sep 9, 2026. doi: 10.5492/wjccm.120702

Table 2 Longitudinal nickel concentrations in relation to methylene blue administration

Timepoint	Blood nickel (μg/L)	Urine nickel (μg/L)	CSF nickel (μg/L)
Baseline (after 1^st dose MB)	15.2	21.0	-
Before 3^rd dose MB	7.4	8.8	55.5
After 3^rd dose MB	4.8	51.9	-
48 hours post-3^rd dose	3.7	1.8	-
72 hours post-3^rd dose	2.1	5.6	-
96 hours post-3^rd dose	0.0	0.0	-
Reference range	0.14-0.65	< 5.2	-

The ingested toilet cleaner concentration was 3468 μg/L. All levels were analyzed using inductively coupled plasma mass spectrometry. MB: Methylene blue; CSF: Cerebrospinal fluid.

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Citation: Hosur Ravikumar R, Nath S, Quadri JA, Bhattacharjee S. Methylene blue for treating toxic encephalopathy due to acute nickel poisoning: A case report. World J Crit Care Med 2026; 15(3): 120702
URL: https://www.wjgnet.com/2220-3141/full/v15/i3/120702.htm
DOI: https://dx.doi.org/10.5492/wjccm.120702

Hosur Ravikumar R, Nath S, Quadri JA, Bhattacharjee S. Methylene blue for treating toxic encephalopathy due to acute nickel poisoning: A case report. World J Crit Care Med 2026; 15(3): 120702 [DOI: 10.5492/wjccm.120702]

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